Open Access

Removal of an Intrauterine Polypoid Lesion Resolved Chemotherapy-resistant Gestational Trophoblastic Neoplasia: A Case Report


1Department of Obstetrics and Gynecology, Chiba University Hospital, Chiba University, Chiba, Japan

2Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan

3Department of Evolution and Reproductive Medicine, Medical Mycology Research Center, Chiba University, Chiba, Japan

Cancer Diagnosis & Prognosis Mar-Apr; 4(2): 193-197 DOI: 10.21873/cdp.10307
Received 07 December 2023 | Revised 13 April 2024 | Accepted 12 January 2024
Corresponding author
Hirokazu Usui, MD, Ph.D., Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba 2608670, Japan. Tel: +81 432262121, Fax: +81 432262122, email:


Background/Aim: Single-agent chemotherapy typically has curative outcomes in patients with low-risk gestational trophoblastic neoplasia (GTN). Although surgical intervention is a potential alternative, its efficacy in these patients remains unclear. This report describes a case in which surgical excision of a uterine polypoid lesion resolved chemotherapy-resistant low-risk GTN. Case Report: A 43-year-old patient received pulse actinomycin D treatment for post-molar low-risk GTN without extrauterine metastasis. However, the patient showed resistance to the chemotherapy regimen. There was no initial evidence of protrusion of GTN into the uterine cavity; however, a polypoid lesion grew into the uterine cavity during therapy. This growth was successfully excised via a transvaginal approach using forceps with minimal blood loss. There was a postoperative decrease in human chorionic gonadotropin levels, which ultimately reached the predetermined threshold without the need for changing the therapeutic protocol. Conclusion: Surgical resection should be considered a viable therapeutic strategy for uterine polypoid growth in chemotherapy-resistant low-risk GTN.
Keywords: chemotherapy, drug resistance, gestational trophoblastic neoplasia, surgery

Gestational trophoblastic neoplasia (GTN) is characterized by neoplasms that present trophoblastic proliferation. Moreover, it comprises a spectrum of pathological status, including invasive moles, choriocarcinomas, placental site trophoblastic tumors, and epithelioid trophoblastic tumors. Notably, approximately 15% of complete hydatidiform moles and 1-4% of partial hydatidiform moles may progress to GTN (1,2). Most post-molar GTNs are categorized as low-risk GTN based on the International Federation of Gynecology and Obstetrics (FIGO) 2000 scoring system (3).

Low-risk GTNs generally exhibit a high degree of chemosensitivity. Monotherapy with chemotherapeutic agents, including methotrexate or actinomycin D, is the primary intervention for low-risk GTN (4,5). However, 10-40% of these patients may require changes in the treatment protocol due to the emergence of drug resistance or adverse reactions (6-8). Nonetheless, almost all patients with low-risk GTN can be successfully treated with chemotherapy even though 5-30% of these patients require a combination of chemotherapeutic agents to achieve remission (9-12).

Surgical intervention is another effective therapeutic modality for GTN. Osborne and colleagues reported that secondary curettage alone yielded a cure rate of 40% in patients with nonmetastatic low-risk GTN (13). Additionally, hysterectomy has been shown to yield an 82% cure rate in patients with nonmetastatic low-risk GTN without the need for adjunctive chemotherapy (14). However, hysterectomy may not be preferred by individuals who want to preserve their fertility.

This report describes a case in which surgical excision of a uterine polypoid lesion was effective in treating chemotherapy-resistant low-risk GTN.

Case Report

A 43-year-old woman presented to our hospital with a suspected molar pregnancy. Her preoperative serum human chorionic gonadotropin (hCG) level was extremely high (662,869 mIU/ml). She underwent dilation and evacuation through vacuum aspiration (Figure 1) (15). Histopathological evaluation revealed a complete hydatidiform mole with negative p57KIP2 staining. Molecular genotyping via short tandem repeat polymorphism analysis indicated an androgenetic diploid genotype (2), which was consistent with the histopathological diagnosis.

After two weeks, a second dilation and curettage was needed due to persistent molar gestational tissue within the uterine cavity (Figure 2A). Small amount of tissue was retrieved. The pathological examination confirmed residual molar villi and trophoblasts.

Her serum hCG levels continued to increase after two weeks of the second surgery to 7,759 mIU/ml. Transvaginal ultrasonography revealed a hypervascular myometrial lesion (Figure 2B). Accordingly, the patient was diagnosed with low-risk GTN with a risk score of 2 and stage I based on the FIGO 2000 system, which indicated the absence of extrauterine metastasis (3). The patient was started on a biweekly pulse actinomycin D regimen (1.25 mg/m²). However, serum hCG levels plateaued even after two chemotherapy cycles. At the time of GTN diagnosis, ultrasonography showed an empty uterine cavity (Figure 2B), which was subsequently occupied by an isoechoic, heterogeneous mass concurrent with the plateau in hCG levels (Figure 2C and D).

Hysteroscopic evaluation revealed a long polypoid tumor originating from the uterine fundus, which resembled an invasive mole with morphological changes (Figure 3). Given the pedunculated nature of the tumor and anticipated successful resection, we decided to attempt transvaginal excision before altering the treatment regimen.

The patient was hospitalized for cervical dilation using three laminaria tents. Under intravenous anesthesia and abdominal sonographic guidance, the polypoid tumor was excised using forceps in a 16-min procedure with minimal blood loss. Subsequently, the patient was discharged on the same day. Macroscopic analysis of the excised tissue revealed a fragmented mass (Figure 4A). Microscopic evaluation revealed extravillous trophoblasts in the degenerated and necrotic tissues (Figure 4B).

Following a third curettage, there was a significant decrease in serum hCG levels. Administration of intravenously pulse actinomycin D was continued, with serum hCG levels reaching the predetermined threshold of <1.0 mIU/ml at the start of the sixth treatment cycle. The treatment regimen was stopped after seven cycles (Figure 1). Subsequent follow-up hysteroscopy revealed no residual tumors or adhesions within the uterine cavity. The patient has remained disease-free for four years. Informed consent for the publication of this case report was obtained from the patient.


Our findings show that excision of a intrauterine polypoid growth of low-risk GTN can be a viable treatment alternative for chemotherapy-resistant low-risk GTN. The excision would decrease the number of chemotherapy cycles or prevent having to switch to a multiple-agent regimen.

There have been few reports of polypoid lesions growing in patients with low-risk GTN undergoing chemotherapy. However, a similar case involving a placental polyp arising from an exaggerated implantation site has been reported (16). A placental polyp is a remnant of conception, which results in the development of pedunculated polypoid tissues within the uterine cavity (17). Its histological characteristics include villous, decidua, thrombotic masses, degenerative and regenerative tissues, and fibrous accretion. Our findings demonstrated that residual villous tissues or extravillous trophoblasts at the implantation site of hydatidiform moles may proliferate given the similar pathophysiology of placental polyps.

The therapeutic efficacy of dilation and evacuation for the management of low-risk GTN has been demonstrated. Osborne et al. observed a 40% remission rate in patients with nonmetastatic low-risk GTN after secondary curettage interventions (13). Unlike this previous study, curettage at GTN diagnosis in our case was not curative. The unfavorable hCG course could be attributed to the intrauterine residual molar tissues or trophoblasts, which had been removed by the second curettage in the previous effective cases. In our case, although the pathogenic trophoblasts did not protrude into the uterine cavity at the time of GTN diagnosis, they proliferated and formed a polypoid tumor during chemotherapy. It is difficult to distinguish between noninvasive and invasive residual molar tissues since pathological examination by hysterectomy is not usually performed to preserve fertility.

Notably, removal of polypoid lesions with myometrial hypervascularity involves a risk of massive bleeding. In our case, there was no significantly enhanced vascularity toward the tumor, and there was minimal intraoperative blood loss. However, trophoblasts can invade the uterine spiral artery to form physiological arteriovenous fistulas. Placental polyps often present myometrial hypervascularity with the accompanying risk of uterine bleeding. In the case of massive hemorrhage, some cases can be treated with invasive procedures such as hysterectomy or uterine artery embolization (18). Dilation and curettage can cause massive hemorrhage in cases of increased myofascial blood flow. We previously reported that cervical ripening can be safely performed using the maximal laminaria technique (19). A similar procedure was performed in this patient. Although the myometrial blood flow was not reduced, the polypoid tumor was safely removed using the transvaginal technique. The use of a Foley’s intrauterine catheter has been shown to effectively control bleeding after the removal of placental polyps (17).

The observed chemoresistance in our case could be attributed to resistance to actinomycin D, ancillary factors such as the pharmacokinetic parameters of drug delivery, or the tumorous condition encompassing hypoxia. In cases where resistance emanates from the first reason, tumor resection alone would be insufficient for a curative effect since the chemotherapy-resistant myometrial lesion would persist and thus require a change in chemotherapeutic regimen. However, remission was achieved in our patient, which indicates the involvement of the drug delivery apparatus or the tumorous condition such as hypoxia in the observed chemoresistance.

In conclusion, we report a case of post-molar low-risk GTN showing polypoid proliferation throughout the course of chemotherapy and plateau of hCG levels. The intracavitary region of the polypoid lesion was safely removed, which helped avoid alteration of the chemotherapeutic regimen. Therefore, the removal of a uterine polypoid tumor can be a viable treatment option for low-risk chemotherapy-resistant GTN.

Conflicts of Interest

The Authors have no conflicts of interest to declare in relation to this study.

Authors’ Contributions

Asuka Sato: Conceptualization; data curation; formal analysis; funding acquisition; writing – original draft; writing – review and editing. Hirokazu Usui: Conceptualization; data curation, formal analysis, funding acquisition, project administration, supervision; writing the original draft, writing the review, and editing. Natsuko Nakamura: Data curation; writing – review & editing. Eri Katayama: Data curation; writing – review & editing. Makio Shozu: Supervision; writing – review & editing. Kaori Koga: Conceptualization; supervision; writing - review & editing.


The Authors are grateful to the staff of the Department of Obstetrics and Gynecology, Chiba University Hospital, Chiba, Japan, for treating the patients.


This study was partially supported by JSPS KAKENHI (grant numbers JP17K16831 [AS], JP18K09281, JP21K19551, and JP22H03220 [HU]). The funding source had no role in the study design; collection, analysis, or interpretation of the data; writing of the report; or in the decision to submit the article for publication.


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